(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2 Purity (GC) ≥99.0% e.e ≥99.0%
Ruifu Chemical is the leading manufacturer of (S)-(+)-3-Hydroxytetrahydrofuran (CAS: 86087-23-2) with high quality. Please contact us by e-mail:alvin@ruifuchem.com
| 화학명 | (S)-(+)-3-Hydroxytetrahydrofuran |
| 동의어 | (S)-Tetrahydrofuran-3-ol |
| 재고현황 | In Stock, Commercial Production |
| CAS 번호 | 86087-23-2 |
| 분자식 | C4H8O2 |
| 분자량 | 88.11 |
| 아이넥스 | 425-090-2 |
| Boiling Point | 80℃/15 mmHg (lit.) |
| 밀도 | 1.103 g/mL at 25℃(lit.) |
| Refractive Index | n20/D 1.45(점등) |
| Water Solubility | 가용성 |
| Storage Temperature | Sealed, Store at Cool and Dry Place |
| 안정성 | Stable. Combustible. Incompatible with strong oxidizing agents. |
| Shipping Conditions | 주변 |
| COA 및 MSDS | 가능 |
| Origin of Product | 중국 상하이 |
| 브랜드 | 루이푸 화학 |
| 품목 | 사양 | 결과 |
| 외관 | Colorless transparent to light yellow liquid | Colorless transparent liquid |
| Identification (By GC) | Retention time of the sample should match with the retention time of reference standard | 준수 |
| Water by Karl Fischer | 0.50% 이하 | 0.05% |
| 특정 회전 | +15.0°~ +20.0°(C=2,MeOH) | +18.2° |
| 광학 순도 | ≥99.0% | 99.90% |
| 순도(GC) | ≥99.0% | 99.81% |
| (R)-(-)-3-Hydroxytetrahydrofyran | 0.15% 이하 | 0.05% |
| Related Substances | ||
| 기타 불순물 | 0.40% 이하 | 0.10% |
| 총 불순물 | 1.0% 이하 | 0.19% |
| 결론 | The product has been tested and complies with the given specifications | |
패키지:Bottle, 25kg/drum, or according to customer's requirement.
보관 조건:Keep the container tightly closed. Store in a cool, dry and well-ventilated warehouse.
배송:Deliver to worldwide by air, by sea, by FedEx. Provide fast and reliable delivery.
86087-23-2 - Risk and Safety:
Hazard Symbols Xi - Irritant
Risk Codes 36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39 - Wear suitable gloves and eye/face protection
UN IDs NA 1993 / PGIII
WGK 독일 3
HS Code 29321900
(S)-(+)-3-Hydroxytetrahydrofuran (CAS: 86087-23-2) is a useful pharmaceutical intermediate. (S)-(+)-3-Hydroxytetrahydrofuran is an intermediate to the AIDS drugs amprenavir and fosamprenavir. Additionally, it has been an intermediate to developmental drug substances, such as chemotherapy agents.
86087-23-2 - 모아:
1. 테스트 방법
Add approximately 0.5g sample in 5ml methanol. Inject a methanol blank, followed
by the composite samples.
GC Conditions as follow:
Column: Agilent J&W Rtx-1 (30M*0.25mm*0.25um)
Lenth 30M, LD 0.25mm, film 0.25um
Injection Mode: Split
Injection Temp: 280℃
Column Flow: 1.0 ml/min (N2)
Purge Flow: 3.0ml/min (N2)
분할 비율: 30
Column Temp: 60℃ hold 2minutes, 10℃/min to 90℃, hold 3minutes, 25℃/min
to280℃, hold 1.4minutes
감지기 유형: FID
Detector Temp: 300℃
Method of derivatization: To a 100ml round-bottom flask with a magnetic stirring bar was
added (S)-(+)-3-hydroxytetrahydrofuran (0.088g, 1.0 mmol, 1.0 equiv), 4-Dimethylaminopyridine
(30mg) and CH2Cl2 (10ml). Pyridine (0.3 ml, 3.0 mmol, 3.0 equiv) was added via syringe. The
solution was cooled to 0℃ prior to addition of Ac2O (0.19 ml, 2.0 mmol, 2.0 equiv). The reaction
mixture was stirred for 12 hours at room temperature. The aqueous layer was extracted with ethyl
acetate (3 × 50 ml). The combined organic extracts were washed with water (50 ml), brine (50 ml)
and dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The residual crude
product was purified by flash column chromatography.
EE%의 시험 방법
The derivative was used to test theEE% via GC.
GC Conditions as follow:
Column: BETA DEX 120 (30M*0.25mm*0.25um)
Lenth 30M, I.D. 0.25mm, film 0.25um
Injection Mode: Split
Injection Temp: 220℃
Column Flow: 0.6 ml/min (N2)
Purge Flow: 5.0ml/min (N2)
WXZKQA:007(HL008)
분할 비율: 80
Column Temp: 60℃ hold 2 minutes, 4.5℃/min to 150℃, hold 0 minutes, 50℃/min to 200℃, hold 4minutes
감지기 유형: FID
Detector Temp: 250℃
